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In support of this latter idea, glutamate released by astrocytes has been shown to regulate migrating neuroblasts in the rostro-migratory stream (Platel et al. 2010).
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The tACE is known to regulate sperm migrating ability into oviduct and binding ability to zona pellucida of eggs [8], [9].
Our demonstrations that Erk activity and regional regulation of Eps8 activity are essential to leader bleb formation suggests that Erk activity itself may be regionally regulated in migrating melanoma cells.
In the present paper, we will give a brief overview about how Ca2+ signaling is polarized and regulated in migrating cells, its local actions on the cytoskeleton, and its global effect on cell migration and cancer metastasis.
In all cell line tested, Mitostatin over-expression inhibited the ability of cells to migrate (Figure 3A) indicating that Mitostatin negatively regulates migration of prostate cancer cells.
Moreover, keratinocytes in the normal wound healing process are regulated to migrate toward the denuded area on the provisional matrix in response to specific cytokines and ECM proteins.
Moreover, the keratinocytes in normal wound healing process are regulated to migrate toward the denuded area on the provisional matrix due to various mechanisms such as cytokines and ECM proteins.
Thus, LRP5 signaling is essential for regulating the sprouting, migrating and/or anastomosing of endothelial cells in the deeper layers of the retina.
These data are consistent with the hypothesis that endocytosis plays a role in regulating adhesion in migrating neurons, but do not rule out other roles for endocytosis or a role for other membrane traffic pathways mediated by clathrin and dynamin.
Besides classical PKCs, atypical PKCs [ 70] also regulate the polarity of migrating cells.
Properties associated with the C-terminus of GRASP65 contribute to growth factor signalling during interphase, and regulate Golgi reorientation in migrating cells.
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