Sentence examples for regulate methylation from inspiring English sources
In order to ask how this local heterogeneity translates into an unmethylated state and if different mechanisms function in different parts of islands, we inserted fragments of CGIs to define their individual potency to regulate methylation and to potentially identify DNA sequence determinants of this regulation.
Folate's job is to regulate methylation.
A previous study has shown that members of the DNMT3 group i.e. DNMT3L, DNMT3A and DNMT3B, can regulate methylation of the Dnmt3L promoter region [11].
In addition to the ability of c-myc to bind 10 15% of the promoters in the human genome, it is likely to affect the transcription of even a larger proportion of the genome by its ability to regulate methylation patterns [39] [42].
It is conceivable that this extra base-pairing interaction might regulate methylation activity.
Because promoter hypermethylation is potentially reversible, the molecules that regulate methylation status of DNA are considered promising targets for new cancer therapies.
Therefore, combined action of drugs regulating methylation and acetylation is worth intensive investigation.
SAH is actually more crucial than SAM in regulating methylation reactions (Yi et al. 2000).
We find strong support for the classical model of genetic variants regulating methylation, which in turn regulates gene expression.
This raises the possibility that aberrant methylation in embryonal tumours such as medulloblastoma may reflect a failure of developmentally regulated methylation changes.
Results from causality analyses indicate that the conventional model of genetic variants regulating methylation, which in turn regulates gene expression, is most common.
