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That Ames dwarfs were also long-lived gave credence to the idea that the same genetic pathway might regulate life span in worms and in mammals.
In invertebrates, the molecular genetic pathways that regulate life span and senescence are being identified; surprisingly, they are conserved through evolution.
Several genes that regulate life span (e.g., Superoxide dismutase, Catalase, and rosy) complemented the life span effects of wild-derived alleles, suggesting little natural variation affecting longevity at these loci, at least in this sample of alleles.
Therefore, one way that sexual differentiation genes might regulate life span is by modulating germ cell development.
RIM15, GIS1, and MSN2/4 are effectors of Tor1, Sch9, and Ras2, which are also shown to regulate life span.
Based on these reports, RasGrf1 has been identified as a gene that may regulate life span in mice.
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A signal from the gonad also regulates life span in C. elegans.
We asked, therefore, whether THC also regulates life span under normal conditions.
foxo regulates life span through the insulin signaling pathway [ 1, 28, 29].
Although there are indications that RES may not extend life span in Drosophila, our studies support the hypothesis that RES indeed regulates life span through Sir2 activity [ 30].
Given its apparent conservation across eukarya (Blagosklonny and Hall 2009), elucidation of the mechanisms by which TORC1 regulates life span is eagerly awaited.
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