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RNA is usually associated with RNA-binding proteins (RBPs) which serve to either protect, stabilize or transport it and regulate its interaction with other molecules 3, 4. RNA plays many crucial roles in protein synthesis, transcriptional regulation and retroviral replication that make it a prime target for drug action.
Alternatively, phosphorylation of GCP-WD by Plk1 might regulate its interaction with the centrosome.
Another FHA domain containing protein, GarA [43] has been found to be phosphorylated by two kinases, PknG and PknB which differentially regulate its interaction with other proteins.
Since S-nitrosation has been reported to facilitate protein-protein interactions [9], we speculated that NO-mediated specific molecular modification of Pias3 (or Trim32) might regulate its interaction with Trim32 (or Pias3).
Changes in K protein phosphorylation regulate its interaction with nucleic acids and protein partners (Schullery et al, 1999; Ostrowski et al, 2000a; Ostareck-Lederer et al, 2002).
This will be the focus of future work but one possibility is that SUMOylation of Drp1 may regulate its interaction with the mitochondrial anionic phospholipid cardiolipin (Montessuit et al, 2010).
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The phosphorylation of β-dystroglycan on tyrosine acts as a molecular switch to regulate its interactions between different potential binding partners and different cellular adhesion functions (28).
Our results further suggest it is also important for regulating its interaction with RNAP II.
ATM not only interacted with YAP1 but also regulated its interaction with p73 and p300.
Open image in new window Figure 2 EB1 phosphorylation at Y217 regulates its interaction with other +TIPs as well as its dimerization.
In addition, we demonstrate that EB1 phosphorylation at Y217 regulates its interaction with other +TIPs and the equilibrium of EB1 between monomer and dimer forms.
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Justyna Jupowicz-Kozak
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