Sentence examples for regulate its activity from inspiring English sources

While studies to date in nonneuronal cells have suggested that PKA may phosphorylate Rho-A and negatively regulate its activity, it is unclear whether this mechanism occurs in cyclic AMP-PKA-mediated relief of neurite outgrowth inhibition on myelin.

On the other hand, ctrA is regulated at the levels of transcription, phosphorylation, and proteolytic degradation by its target genes, e.g., DNA methyltransferase (CcrM) regulates the transcription of ctrA, histidine kinases (CckA, PleC, DivJ, DivL) regulate its activity, and ClpXP degrades it.

Because nvp63 itself is transcribed from a strong constitutively active expression plasmid, it is likely that post-translational modifications may regulate its activity by inactivation of the putative C-terminal TID.

Taken together, these findings indicate that PKD plays multiple important roles in cardiac myocytes, making it imperative to better understand the mechanisms that regulate its activity in this cell type.

OTULIN is subject to phosphorylation, acetylation, and ubiquitination in cells, and it will be interesting to study whether these modifications regulate its activity or function.

DAXX also interacts with p53 to regulate its activity by competitive interaction with PML (Kim et al., 2003).

Oligomerization of Cdc24 has also been proposed to regulate its activity [41].

Our study suggested that the interaction of bacosides (A3/A) with TPH might up-regulate its activity to elevate the biosynthesis of 5-HT, thereby enhances learning and memory formation.

Shedding of active tissue kallikrein in the urine may also represent a rapid means to down-regulate its activity.

P16 protein is a known inhibitor of cyclin-dependent kinase 4 (CDK4) that binds to CDK4 in the G1 phase of the cell cycle to down-regulate its activity.

It appears therefore that the phosphorylation of paxillin at specific serine/threonine residues could regulate its activity and biological functions.