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While FoxO could mediate gene repression through direct binding to gene promoters, as has been documented previously [ 54– 56], FoxO may also regulate gene repression through indirect mechanisms.
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Euchromatic histone-lysine N-methyltransferase 2 (EHMT2, also known as G9a) is believed to be dominant in catalysing H3K9me2 and regulates gene repression [ 4].
The information appears to influence and help guide or regulate gene activity and repression in subsequent generations.
The notion of DNA motif is a mathematical abstraction used to model regions of the DNA (known as Transcription Factor Binding Sites, or TFBSs) that are bound by a given Transcription Factor to regulate gene expression or repression.
MicroRNAs (miRNAs) are endogenously produced small RNAs that regulate gene expression by translational repression and/or mRNA degradation [1], [2].
MicroRNAs are a class of small, evolutionarily conserved RNA molecules that negatively regulate gene expression, causing translational repression and/or messenger RNA degradation.
As a new family of small non-coding RNA molecules with approximately 22 nucleotides, miRNAs regulate gene expression through translational repression or mRNA degradation in a sequence-specific manner [1] [4].
In animals, miRNAs are thought to regulate gene expression by mediating repression of protein synthesis and/or destabilization of mRNAs [5], although recent studies have indicated that in the majority of reported cases, a reduction in protein synthesis can be explained by direct down-regulation of target mRNA levels [6], [7].
They regulate gene expression through translational repression and mRNA degradation.
Histone deacetylation is known to regulate gene expression by transcriptional repression in eukaryotes [ 38].
MicroRNAs are tiny non-coding small endogenous RNAs that regulate gene expression by translational repression, mRNA cleavage and mRNA inhibition.
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