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D2 autoreceptors regulate dopamine release throughout the brain.
They regulate dopamine release and are located densely in the brain's mesocorticolimbic region.
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Zhou, F. M., Liang, Y. & Dani, J. A. Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum.
Snca encodes α-synuclein neurotransmitter that regulates dopamine release and transport [56].
This may provide feedback that regulates dopamine release and hence learning.
Rewarding properties of morphine are produced via inhibition of GABAergic midbrain interneurons that negatively regulate dopamine neuron firing and dopamine release [36].
So, what we're beginning to understand is that early exposure to drugs of abuse may change the epigenetic control of areas that regulate emotion or regulate even dopamine release.
Some of the 12 are primarily involved in regulating dopamine in the prefrontal cortex, while others primarily regulate dopamine in the striatum.
The medial prefrontal and orbitofrontal cortices differentially regulate dopamine system function.
The prevailing explanation is called "The Dopamine Hypothesis," and my amateurish understanding is that schizophrenia is caused by the brain's inability to regulate dopamine production and reception.
Alternatively, FruM may regulate dopamine neuronal activities.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com