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The chemokine CXCL12 and its shared seven-transmembrane receptors CXCR4 and CXCR7 regulate diseases including cancer, atherosclerosis, autoimmunity, and HIV infection, making these molecules promising drug targets.
MicroRNAs (miRNAs) have increasingly been found to regulate diseases at a significant level.
These associations can help to identify critical pathways, genes and proteins that regulate biological processes, and in turn provide better drug targets to regulate diseases.
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For example, the bacterium Pseudomonas aeruginosa, which can cause pneumonia and blood infections, uses quorum sensing to regulate disease mechanisms.
Microglia are resident immunocompenent and phagocytic cells of central nervous system (CNS), which produce various cytokines and growth factors in response to injury and thereby regulate disease pathology.
These findings suggest that the up-regulation of CD73 is an important purinergic remodeling response in environments where adenosine has been shown to regulate disease.
Other genes that regulate disease by differential splice-variant expression are IL2RA and IL7R, which may involve dysregulation of their membrane-bound and soluble forms in MS patients [12], [72], [73].
A fundamental view is that aberrant miRNA can regulate disease progression-related biological processes [ 57].
How these competing signals regulate disease pathogenesis at the molecular level is not clear.
The molecular mechanisms by which CaMs may regulate disease resistance are unknown.
Discovered markers may also define a subset of networked causal genes that regulate disease phenotype.
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