Sentence examples for regulate chip from inspiring English sources

Other members of the BAG family of co-chaperone proteins, including BAG1 [23] and BAG2 [33], [33], have been previously found to interact with and regulate CHIP function.

We therefore suspected that H2O2 might regulate CHIP protein expression or its binding with SENP3.

More recently, S100A2 has also been shown to regulate CHIP itself.

Altering the expression level of the CHIP-inhibitor could allow to regulate CHIP-mediated ubiquitylation in the course of immune cell maturation without changing the level of the ubiquitin ligase.

The identity of molecules responsible for regulating CHIP-mediated ubiquitinylation of α-syn and reduction of α-syn oligomerization by CHIP is unknown.

Taking our data together, we conclude that the CHIP-BAG5 interaction negatively regulates CHIP-mediated reduction of α-syn oligomerization.

To understand which genes it regulates, ChIP-chip was performed on samples collected 9 hours after transfer to sporulation medium (see Methods).

The supporting evidence is as follows: (1) EndoG stability was regulated by CHIP via the ubiquitin proteasome system; (2) EndoG ubiquitination was diminished in CHIP-depleted cells; (3) CHIP expression downregulated EndoG levels in breast cancer cells and primary rat cortical neurons; (4) elevated EndoG levels in the aged mouse brain are inversely correlated with CHIP levels.

Interestingly, in normal conditions EndoG levels are pre-regulated by CHIP prior to oxidative stress.

Radovanac et al. demonstrated that ILK stability is negatively regulated by CHIP ubiquitination in fibroblasts when HSP90 is inhibited [ 26].

Our results show that TGF-β was able to regulate GATA-3 ChIP enrichment of the IL-13 gene, resulting in the respective stimulation or inhibition of IL-13 expression in patients with SSc and in healthy donors.