Collectively, these studies suggest a physical and functional role for Merlin in regulating cell:cell adhesion, transmembrane signalling receptors, Rho-GTPase signalling, and in modulating actin cytoskeleton dynamics.
Windus, L. C., Claxton, C., Allen, C. L., Key, B. & St John, J. A. Motile membrane protrusions regulate cell-cell adhesion and migration of olfactory ensheathing glia.
We hypothesized that mechanical stimuli in the form of microenvironmental stiffness, cytoskeletal architecture, or cyclic stretch regulate cell-cell junction formation and cytoskeletal remodeling during development and disease.
By fine-tuning the nanoenvironment, it may be possible to regulate cell-cell communications and optimize the biocompatibility of neural implants.
In Science (512 December, 2003; 302: 1984-1988) he described the first known longitudinal signals: Wnt proteins, which are known to regulate cell-cell interactions in embryonic development.
As a class of structurally unrelated ECM proteins, matricellular proteins serve as links between the ECM and cells to regulate cell-cell and cell-matrix interactions, and their functions are highly dependent upon the cues from local microenvironment.
EVs are involved in NAFLD pathology because they regulate cell-cell communication and a number of pathophysiological events in various types of cells via horizontal transfer of their cargo including proteins (membrane, cytosolic, and nuclear), RNAs (including mRNAs and microRNAs), and lipids (Yuan et al., 2009, Diehl et al., 2012, Raposo and Stoorvogel, 2013).
In summary, saliva exosomes may regulate cell-cell environment by altering their gene expression.
It has been established that cadherins, including CDH1 and CDH2, regulate cell-cell interactions through homophilic binding [55].
TJ control the barrier function of epithelia and maintain cell polarity, and AJ regulate cell-cell adhesion and morphogenesis [2], [3].
Therefore, we concluded from these experiments that Src is not directly involved in the adhesive function of ICAM-1, but rather in transmitting intracellular signals downstream from ICAM-1 clustering, possibly to regulate cell-cell junction integrity [30].
