The crystal structure of PKCβII in a partially activated conformation showed how the C1B domain regulates activity by clamping a helix in the C-terminal AGC extension of the kinase domain.
Additional enzymes in which H2S regulates activity by metal chelation include cytochrome c oxidase (complex IV), carbonic anhydrase, and some NOS isoforms.
From our data, we conclude that alternative splicing is a further means to regulate AID activity by regulating the amount of available AID-FL transcripts.
Members of the multiple antibiotic resistance regulator (MarR) family often regulate gene activity by responding to a specific ligand.
Previous studies showed that hnRNP K can regulate promoter activity by interacting with DNA-bound transcriptional activators [ 7, 62].
Conversely, GTPase activating proteins, Ira1 and Ira2, down regulate Ras2 activity by stimulating the hydrolysis of GTP [ 21, 22].
Traditionally, the government regulates political activity by regulating the flow of money -- how much campaign money is raised and spent, who gets it and who gives it.
TORC1 regulates permease activity by regulating not only permease localization but also expression.
These data suggest that, in addition to promoting zymogen activation, cell surface binding of MMP-2 may regulate enzyme activity by increasing the rate of substrate cleavage.
In particular, the GEFs regulate GTPase activity by exchanging the inactive, GDP-bound Rac to the active, GTP-bound state.
GPER also regulates transcriptional activity by activating signaling pathways that involve cAMP, ERK, PI3K, and c-Fos [ 31].
