Sentence examples for regulate a significant from inspiring English sources

Analysing LCP and a subset of ICP genes (CpG ratio <0.5), we discovered GATA family transcription factors that are predicted to regulate a significant subset of these genes.

Also, we wished to obtain a list of TF pairs which regulate a significant number of common target genes (referred to as co-regulatory TF pairs).

In addition, nonsense-mediated mRNA decay (NMD) is known to regulate a significant number of genes under physiological conditions [ 19], as well as to prevent incorrectly spliced genes from being translated [ 20].

Therefore, genes down-regulated after CREB depletion is generally down regulated after fusion depletion, and vice versa, strongly supporting that the CRTC1-MAML2 fusinteractsacts with CREB to positively regulate a significant percentage of its direct target genes in MEC.

The MAP kinase signaling cascade regulates a significant number of processes in fungi including the regulation of tyrosinase (Park et al. 2008).

We defined two pairs of transcription factors as functionally similar if they jointly co-regulate a significant number of target genes.

Nonsense-mediated messenger RNA (mRNA) decay (NMD) is a mRNA degradation pathway that regulates a significant portion of the transcriptome.

We have identified 168 candidate direct NMD targets, indicating that NMD regulates a significant proportion of the Drosophila genome.

For example, while GeneSet2miRNA [6] can predict a group of miRNAs regulating a significant subset of genes, the prediction of statistically enriched biological functions regulated by these miRNAs is missing in this tool.

For example, transcriptional analysis of BPA exposure on breast cancer cells (MCF-7) revealed that BPA up-regulated a significant number of genes involved in cell cycle progression and purine and pyrimidine metabolism (Shioda et al. 2006), reaffirming the proliferative biological action of this compound in estrogen-dependent tissues.

In analogy to the spleen our IPA analysis revealed that Bapx1 regulates a significant proportion of proliferation (z-score: -3.054; p: 2.22E-05) apoptoticotic genes (p: 3.01E-03) in the gut, thus explaining the shortening of the antrum-pylorus segment in the null embryo (Additional file 2: Table S2).