Exact(1)
There were also unique transcriptional changes seen in Rag2−/− cells that were not found in the CD2 C3 DN3Supplementaryary Fig. 4) which indicates that the pre-TCR can regulate a program of gene transcription via RhoA independent pathways The unique changes in Rag2−/− cells not surprisingly included loss of expression of rearranged TCR-β subunits.
Similar(59)
Instead, fd3F regulates a program of gene expression for mechanosensory specialization that is unique to Ch neuron cilia and is absolutely required for their response to sensory stimulation.
A hallmark of p53 function is to regulate a transcriptional program in response to extracellular and intracellular stress that directs cell cycle arrest, apoptosis, and cellular senescence.
E. Bergamini and colleagues proposed a method to evaluate wheelchair propulsion based on biomechanics and successfully applied the results to regulate a training program for young wheelchair athletes.
Thus, a signalling pathway can function at multiple levels to positively regulate a developmental program and can function by abrogating inhibitory pathways.
We have placed these genes in a Foxa2-dependent genetic regulatory network and we hypothesize how Foxa2 may regulate a molecular program of Spemann/Mangold organizer development.
However, this factor has been shown to regulate a gene program that is clearly distinct from full-length PGC-1α [ 42].
For example, Wnt/β-catenin signaling could regulate a transcriptional program that is required for tip cell function but plays no role in tip cell selection or, alternatively, tip cells could be selected through a specific transcriptional program that is only initiated by a certain threshold level of Wnt/β-catenin activity.
Nonetheless, these nine candidate miRNAs likely target hundreds of genes to regulate a complex differentiation program that specifies the trophectoderm.
The final existence of a senescence associated program remains to be proven and specific factors that would activate or regulate such a program are yet unknown.
Like many other established signal transduction pathways, Hippo signaling regulates a transcriptional program.
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