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Moreover, TNF signaling also regulates a fine tune balance of pro- and anti-apoptotic factors that control EC survival and, ultimately, vascular injury and remodeling [19].
The number of cells entering the cell division cycle is regulated by a fine balance of cell cycle proteins.
Angiogenesis is regulated by a fine balance between factors that stimulate the formation of new blood vessels and those that inhibit it [24], [25].
CSC growth is regulated by a fine balance between self-renewal and differentiation.
Ovarian folliculogenesis is regulated by a fine balance between extra and intra-ovarian factors (Artini et al., 2007).
The cytolytic activity of NK cells is regulated by a fine balance of activating and inhibitory NK cell receptors.
Although this seems contrary to its MAO-A inhibition profile, because brain functions are regulated by a fine balance of monoamines, we believe that this is not so.
Furthermore, it has also been suggested that Rho GTPases are regulated by a fine balance between GEF and GAP activities, and that the inactivation of GAP activity is a physiologically important regulatory mechanism for activating Rho GTPases [ 19].
It is desirable to have model-based, fine-tuned external control approaches to precisely regulate a reverse-engineered target.
These complex systems determine a fine equilibrium which regulates the vascular tone.
In S. cerevisiae, it is well known that a skewed ratio of cytosolic NADH/NAD+ can be compensated by glycerol production regulated by a fine-tuned expression of the GPD2 gene (Ansell et al. [1997]; Björkqvist et al. [1997]).
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