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The primary physiological role of the RyR is to provide a ligand-regulated pathway for the release of stored Ca2+ to regulate a diverse array of cellular processes.
In this review, we detail how cardiac-specific TFs function in concert with nucleosome remodeling and histone-modifying enzymes to regulate a diverse network of genes required for processes such as cell growth and proliferation, or epithelial to mesenchymal transition (EMT), for instance.
Gbetagamma subunits can regulate a diverse array of effectors, including ion channels and enzymes.
Gβγ subunits can regulate a diverse array of effectors, including ion channels and enzymes.
Calcium (Ca2+) signals regulate a diverse set of cellular responses, from proliferation to muscular contraction and neuro-endocrine secretion.
Nitric oxide (NO), is another important signaling molecule that acts in many tissues to regulate a diverse range of physiological processes (Moncada et al. 1991).
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Cortisol regulates a diverse array of systems including metabolism, ion regulation, growth and reproduction [ 162].
mTOR complex 2 (mTORC2) is regulated by growth factor signaling and regulates a diverse set of substrates, including specific regulatory residues of AKT, serum/glucocorticoid regulated kinase (SGK), and protein kinase C α (PKCα).
The promoter binding TF complex NF-Y regulates a diverse set of constitutive, inducible, developmental, oncogenic and tissue-specific genes.
The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular pathways through dedicated substrate receptors (DCAFs).
Keshet, Y. & Seger, R. The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions.
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