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To Republicans who have fought to limit the agency created in the aftermath of the financial crisis, the algorithm encapsulates how the CFPB has overstepped its bounds, using a novel statistical method to indirectly regulate a class of businesses — car dealers — outside its jurisdiction.
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As the chapter shows, there is no one-size-fits-all approach to regulating a class of product, and factors beyond just science and scientific uncertainty will drive the design and implementation of a regulatory regime.
Vvi-miR395, whose abundance decreases from pre- veraison to maturity, as already reported in [ 25], down-regulates a class 2-sulphate transporter and it has been usually involved in sulphur uptake and assimilation, or in nutrient starvation response [ 90– 92].
Phosphorylation of p100 leads to its ubiquitination and partial proteasomal processing into mature p52 subunits, resulting in transcriptionally competent RelB/p52 complexes that translocate to the nucleus and regulate a distinct class of genes [ 42].
Fatty acid amide hydrolase (FAAH) regulates a large class of signaling lipids, including the endocannabinoid anandamide.
Intestinal permeability recently has been found to be regulated by a class of endogenously expressed noncoding RNAs (21 23 nucleotides in length) known as microRNAs.
PKA activity is further regulated by a class of proteins called A kinase- anchoring proteins (AKAPs).
This process is regulated by a class of proteins called chemokines as well as many small-molecule chemoattractants [ 25].
In the presence of oxygen (normoxia), HIF-α is regulated by a class of dioxygenases called prolyl-hydroxylases (PHD1, PHD2 and PHD3) (Kaelin, 2005).
If a sponsor is considering utilizing the De Novo pathway, the sponsor should engage with FDA through the presubmission process to craft an intended use statement that will allow the biomarker test to be regulated as a Class II device.
The classic model for autophagy is derived from starvation-induced autophagy where the autophagic machinery is thought to be regulated by a class III phosphatidylinositol 3-kinase (PI3K) complex of which beclin1 is a key player [ 2, 9, 10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com