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Caffeine pre-treatment abolished FPL-mediated arrhythmic effects during intrinsic, regular pacing in six hearts.
The occurrence of such arrhythmias during intrinsic rhythm or during regular pacing requires initiation by a triggering event.
Figure 1a shows that during 8 Hz regular pacing metabolic acidification was associated with the appearance of spontaneously generated APs.
In addition, ventricular tachycardia (VT) was observed both during 8 Hz regular pacing and during intrinsic rhythm.
Nevertheless, withdrawal of the regular pacing permitting resumption of normal intrinsic activity led to restoration of normal 1 : 1 AV conduction once pharmacological agents were withdrawn.
Finally, with pre-treatment with CPA combined with a further addition of FPL in five hearts, none of the hearts showed arrhythmogenesis during either intrinsic or regular pacing.
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