This can be explained by viewing the epigenetic modification as producing an epi-mutation that has a similar effect as a regular mutation event if the epi-mutation persists a relatively long time in a population, i.e., if transmissible between generations.
Moreover, Acquisti et al. hypothesized that regular point mutations, in addition to hypermutable CpGs, are an important justification for the presence of nullomers/unwords [4].
In addition to hypermutable CpG dinucleotides, regular point mutations appear to have played an important role in generating the observed constellation of human nullomers.
A possible mechanism of ARE generation from Alu via retroposition and regular pattern mutation is suggested.
We also use a regular, "divergent" mutate operation, that makes unique mutations in each viral population and is responsible for individual variations between the populations.
We study a particular aspect of structural robustness with respect to mutations: regular protein secondary structure and natively unstructured (intrinsically disordered) regions.
The Mutator tool (7) uses regular expressions to recognize mutations and was tested on mutations related to Fabry disease.
MEMA [ 2] uses regular expressions to extract mutations and mutation-gene pairs.
The definition of a TSG is based on the demonstration of its regular inactivation by mutation or epigenetic silencing in tumour samples.
MuGex [ 5] uses 12 regular expressions to detect mutations and statistical techniques to disambiguate between protein mutations and nucleotide mutations or cell lines.
