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General positional preferences of residues for the given cluster are summarized using regular expression sequence pattern.
Regular expression sequence searches are complemented by a profile Hidden Markov Model (pHMM) analysis allowing the classification of conotoxins that may be only distantly related to well-established conopeptide groups.
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Motif 3 contained a regular-expression sequence "IYIENQ[FY]F".
Motif 4 contained a regular-expression sequence "[GK]GPR[EQ]PWHD[LIV]H[CS][KR][IL][ED]GPA[YW]DVLTNFE[QE]RWRK[AQ]G[G][PW][KD]GLVK" which is thought to form the binding site of PIP2.
The seventh amino acid of this regular-expression sequence, Phe (F), appeared in all PXPH-PLDs, but was often substituted by Tyr (Y) in the C2-PLDs (see Additional file 12).
Each record contains the regular expression and sequence of the motif instance, the UniProt accession, UniProt identifier, gene and organism names of the bait protein containing this instance and sequence position of the bait protein where the instance is located.
LMPID contains information on the regular expression and sequence of the LM instance, the domain interacting with it, the experimental methods used to validate the instance and the PPI, the protein containing the motif (bait) and its interacting partner (prey).
Matching is currently limited to user-specified pattern matching (regular expressions) on sequence identifier/name, sequence content and quality score strings, with defaults set to match all ; however, additional matching and manipulation options can be easily implemented as needed.
The structure of the regular expression is a sequence of identifiers of dictionaries (dictionaries of both objects and keywords).
If a regular expression matches a sequence, we check for the remaining mutations in the set, one after another, taking into account the numbering displacement found when using the regular expression.
TXP is a declarative language that provides a rich set of operators based on regular expressions over sequences of values and events.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com