Sentence examples for regular backbone from inspiring English sources

For the regulation of genomic loci, canonical linkers within a highly regular backbone in combination with a contiguous 18 base pair DNA target site were found to provide a sound base for polydactyl zinc finger design.

Folded protein chains consist of segments with regular backbone structure (primarily α helix or β strand conformations) connected either by turns or by segments with irregular structure (loops).

This suggests that the AST3-88 may have a regular backbone conformation with secondary structure in the pharmacophore region similar to AMW3-130, whash has been reported to have a reverse turn in the similar region.

Finally, the L397P mutation is expected to introduce a kink in H11 (since the cyclization of the proline side chain prevents the regular backbone H bond formation), which will affect the position of D396 and D392 relative to R422 and possibly their interaction.

NMR structural analysis revealed that the three d-amino acids distorted the regular helical backbone structure of GF-17 into a novel nonclassic amphipathic structure of GF-17d3.

An alanyl-PNA oligomer is based on a regular peptide backbone composed of alanyl amino acids that carry covalently linked nucleobases in β-position of the side chain (Fig.  2) (Diederichsen 1997a, b).

Moreover, the circular dichroism spectrum in membranes is different, indicating a change in regular β-sheet backbone structure.

The rule used to differentiate these resembles the distinction between regular and irregular backbone structure in proteins, in that both depend only on local chain conformation.

The S3DB deployment, and by association its query language, S3QL, uses SQL to operate a regular relational database backbone.

This PDB analysis revealed that MoRFs can be divided into three subtypes according to their structures in the bound state: α-MoRFs form α-helices, β-MoRFs form β-strands, and ι-MoRFs form structures without a regular pattern of backbone hydrogen bonds [ 59, 60].

At regular intervals along the backbones two side chains are simultaneously branching off.