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Third, regularised multivariate regression models with cross-validated tuning parameters were used to generate classifier and predictor based resistance gene signatures (REGS) for the combination and individual chemotherapeutic drugs C, H, and O. Fourth, each developed REGS was used to assign resistance levels to individual patients in three clinical cohorts.
Have checked MCC regs for 2013, still no beard ban at Lord's".
Both classifier and predictor based REGS, for the combination CHO, were of prognostic value.
REGS for H developed using HBCCL was initially compared to REGS developed using CGP [ 15].
In order to generate REGS for the combination therapy CHO, the individual drugs C and O were also screened using the HBCCL panel.
The performance of the classifier and predictor based REGS for CHO were compared in terms of area under the ROC curve.
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(By the way, any new regs on for-profits should be applied to nonprofits as well. That's only fair).
Resistance gene signatures (REGSs) for prediction of chemoresistance have been investigated extensively since the development of microarrays.
The classifier and predictor based REGSs for CHO, H, and O were able to predict patient outcome, whereas predictions based on C alone were not.
The focus of this study was to develop REGSs for the combination treatment CHO constituting the main part of R-CHOP first line treatment of DLBCL.
Despite of the controversy associated with the development of in vitro REGSs for prediction of resistance to chemotherapeutics [ 8], we were still encouraged to explore the possibility of establishing cell line derived REGSs for prediction of the efficacy of C, H, and O in DLBCL.
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Justyna Jupowicz-Kozak
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