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Assessment of exposure was performed blinded as to case or control status, as well as coding and registration of exposure for statistical analysis in our studies.
Using a historical cohort design with prospective registration of exposure and the outcome, the study includes a large sample and thus allows better control for known confounders compared with previous studies.
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Strengths of the study included its use of a large national cohort of women with complete prospective registration of exposures and outcomes, including total reproduction of all women in the cohort.
Due to administrative deficiencies in the historic registration of the exposure status, we used our detailed questionnaire data to define exposure status for all workers.
Registration of palivizumab exposure in the DNPR between 1999 and 2010 was compared to two external data sources: registration of palivizumab exposure in medical records, and palivizumab reimbursement data.
This may not be possible within the same studies that measure prevalence and burden, requiring, in addition, the collection and registration of relevant exposure data and follow-up studies.
Registration of palivizumab exposure as recorded in the PDR was assessed by indication for treatment.
Of the 48 children with a registration of palivizumab exposure in the DNPR, 44 children had a registration of palivizumab in the medical records (Table 1).
The registration of objective exposure data can, in the long run, lead to a detailed inventory of the distribution of risks across various sectors and occupations.
In a post hoc analysis, the distribution of baseline factors in children who had a registration of palivizumab exposure only in the medical records, were compared using chi-square tests with children who had a registration of palivizumab in the DNPR and/or reimbursement data.
This would involve continuous monitoring of cause-specific mortality through routine civil registration, regular documentation of exposure to leading risk factors, and monitoring effective coverage of key preventive and curative interventions in the health sector.
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