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How the duration of the registration interval impacts the recording of antibiotic use has not been scrutinized.
The shortest registration interval was one week, and accumulated periods of two, three, and four weeks were also investigated.
The median diagnosis to registration interval appeared to be good (10 weeks), varying significantly with site (P < 0.0001), age (P < 0.0001) and district (P < 0.0001).
Nonetheless, the wide DDD range for oral BSAs (± 21%) even at a four weeks registration interval seems unacceptable by any standards.
Few other studies have evaluated the common method of measuring hospital use of antibiotics by recording pharmacy dispensing or sales data and, to our knowledge, none has previously evaluated the impact of the length of the registration interval.
For all BSAs and parenteral BSAs, limits of agreement of < ± 5% were found for 3- and 4-weeks registration intervals while oral antibiotics (ciprofloxacin) deviated ± 21% from the average mean DDD use even at the 4-week registration interval.
Similar(53)
Moreover, the duration of the registration intervals may affect the results.
However, the appropriateness of using short registration intervals has not been assessed.
In general, short registration intervals have been advocated, especially when the purpose has been to evaluate the effects of specific drug interventions [ 6- 8].
There is a need for caution in interpreting pharmacy sales data aggregated over short registration intervals, especially so for oral formulations.
In particular, we wanted to evaluate the importance of the length of the registration intervals for the reliability of the pharmacy data.
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