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All patients were required to have at least 12 months of continuous registration in the database.
An online registration system was developed and registration in the database began as a pilot study in July 2007.
A lower-than-expected rate of hospitalisation was observed, which could be due to missing registration in the database.
Registration in the database is irrespective of health insurance and is considered representative of the general population.
Data collection consists of registration in the database of women that enrol for a visit to the individual PCC consultations (women successfully recruited), and preconsultation and postconsultation measurements among the included study population (by questionnaires, anthropometric measurements and biomarkers).
As an important aspect of this study was to determine persistence of treatment into adulthood (≥age 18 years), only patients who had continuous registration in the database up to and including age 18 years were included.
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The study population and the sample selected for medical record review are representative of all registrations in the database.
In total, there are 20 141 different Council registrations in the database, including 12 807 registrations for nursing trainings and 7195 midwifery trainings.
We assessed the completeness of registration of patients and follow-up visits, and positive predictive value (PPV), negative predictive value (NPV), sensitivity, and specificity of registrations in the database.
Table 1 lists characteristics of all registrations in the database until August 31 2009, characteristics of the study population (n = 288 patients), and characteristics of the patients registered in the database whose medical records were reviewed (n = 67 patients).
Unfortunately, the registrations in the database of post-mortem findings of some of the remaining 14,519 cases were incomplete because since 1998, lesions typical of certain causes of death have no longer been registered; the descriptions were later completed by data imputation and cases were then classified (see Discussion section).
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