Sentence examples for regions of modification from inspiring English sources
Non protein coding DNA contains many functional elements with influence on gene expression and regulation e.g. RNA coding sequences, transcription factor binding sides, regions of modification or with influence on chromatin (the DNA, RNA and proteins that chromosomes are made of) structure and other interacting regions [88].
We also noted differences among cell types in large broad regions of modification with H3K9me3.
These results indicate substantial variation in activity of the production/maintenance systems for H3K9me3 and for broad regions of modification (H3K27me3 or H3K9me3).
Our results point toward substantial differences among cell types in the activity of the production/maintenance systems for H3K9me3 and for broad regions of modification (H3K27me3 or H3K9me3).
However, our work provides compelling evidence that broad regions of modification should be a focus of future research, in that regions may play important roles in shaping the biology of these cells and may present therapeutic targets.
We use the term "broad modification" to denote long regions of chromosomal space in which there is a given epigenetic modification present continuously (>50 kb), as opposed to focal regions of modification ("peaks") in a promoter or other region.
Best known are "focal peaks", localized regions of epigenetic modification.
Regardless, we speculate that the regions of histone modification in both the mouse and human IGSs are reflective of novel functional elements.
Using this approach, we described several findings of interest, including previously unknown regions of histone modification within rDNA and the association of the insulator-binding protein CTCF with rDNA.
It is thus important to address the effects of these biases because they can influence both the identification and the prioritization of putative transcription factor binding sites or regions of chromatin modification.
Besides, the Encyclopedia of DNA Elements (ENCODE) project is studying different functional elements of human genome including regions of histone modifications.
