Sentence examples for regions of factor from inspiring English sources

However, improvement of some process variables may deteriorate some other criteria due to conflicting regions of factor interests for optimal solution in multi-objective optimization (MOO) processes.

Therefore, a set of fusions of OspA to different regions of factor H binding protein (fHbp), a meningococcal surface-exposed lipoprotein, were designed and tested for their surface-exposure.

This study was undertaken to understand the importance of these two spatially distinct, important regions of factor Va heavy chain when acting in concert on prothrombinase complex assembly and function.

The COOH-terminal region of factor Va heavy chain is involved in the interaction with prothrombin (18, 19).

Our findings using the MD simulations demonstrate that in the presence of the mutations there is a relocation of the COOH-terminal region of factor VaKF and factor VaAA as compared with the wild-type cofactor molecule.

The screening of the first set of recombinants reduced the region of factor 1 from 1.26 Mb (between markers Rga and Antp) to 372 kb (between markers CG15179 and Antp) and to chromosomal location 84A1.

In contrast, Toso and Camire using recombinant proteins have reported that the acidic COOH-terminal region of factor Va heavy chain does not contribute to the increased catalytic activity of prothrombinase with respect to prothrombin activation (38).

This region of factor Va is thought to be important for cofactor function since it is 82% conserved among human (25), bovine (26), mouse (27), and porcine (28) species.

Our findings provide new insights into the structural contribution of the acidic COOH-terminal region of factor Va heavy chain to factor Xa activity within prothrombinase and demonstrate that amino acid region 659−663 from the heavy chain of the cofactor contributes to the regulation of the rate of cleavage of prothrombin by prothrombinase.

Our data demonstrate that the COOH-terminal region of factor Va heavy chain is indeed crucial for coordinated prothrombin activation by prothrombinase because it regulates meizothrombin cleavage at Arg and suggest that this portion of factor Va is partially responsible for the enhanced procoagulant function of prothrombinase.

Using proteins of bovine origin, the authors demonstrated that while elimination of the COOH-terminal region of factor Va results in a molecule with severely impaired clotting activity, incorporation of the truncated cofactor molecule into prothrombinase resulted in an increased kcat for the activation of prothrombin (18).