This type of analysis could be instrumental in defining cell surface marker signatures for different developmental stages in neural induction and regional specification, as well as for specific cell subtypes such as dopaminergic neural progenitors and neurons.
These results indicate that ANP cells have a specific 'adhesion code', according to their regional specification, that leads to the segregation of cells with different prospective fates.
HOX homeobox genes regulate axial regional specification during embryonic development and are often expressed in a tissue-specific and stage-related manner.
Arimatsu, Y. Latexin: a molecular marker for regional specification in the neocortex.
Arimatsu, Y. et al. Early regional specification for a molecular neuronal phenotype in the rat neocortex.
Tailor, J. et al. Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency.
Giudicelli, F., Gilardi-Hebenstreit, P., Mechta-Grigoriou, F., Poquet, C. & Charnay, P. Novel activities of Mafb underlie its dual role in hindbrain segmentation and regional specification.
Sun, Z. & Hopkins, N. vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain.
Considerable improvements in the understanding of the molecular mechanisms underlying NC induction and regional specification have recently led to the development of a robust method to re-create the process in vitro using human pluripotent stem cells (hPSCs).
