A MI did not influence regional insulin-stimulated glucose uptake (R g ) in the heart.
In equine MS, obesity, regional adiposity, insulin resistance, hypertriglyceridaemia and hyperleptinaemia are part of the definition, and it is a risk factor for laminitis, altered reproductive function, and seasonal alterations in arterial blood pressure [ 6, 9].
Equine metabolic syndrome (EMS) was introduced in veterinary medicine in 2002 and is a clinical condition characterized by obesity, regional adiposity, insulin resistance (IR) and clinical or subclinical laminitis [ 1, 2].
Abate, N., Garg, A., Peshock, R. M., Stray-Gundersen, J. & Grundy, S. M. Relationships of generalized and regional adiposity to insulin sensitivity in men.
However, participants were found to have variability in regional and systemic insulin sensitivity.
The association of regional adiposity with insulin resistance and diabetes has been studied in the general population.
Goodpaster, B. H., Kelley, D. E., Wing, R. R., Meier, A. & Thaete, F. L. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity.
The present study was designed to evaluate the effects of 5 weeks treatment with troglitazone on insulin sensitivity, regional hemodynamics, and vascular responses to insulin in chow-fed and high sucrose-fed rats.
Thus, given the large allele-frequency differences of KCNQ1 variants observed in previous studies [15], [16], genotyping and re-sequencing of the KCNQ1 locus and nearby loci on chromosome 11p in additional populations may help identifying the causative variant/s explaining the regional association with reduced insulin release and type 2 diabetes.
Furthermore, WAT LRP5 mRNA levels correlated with measures of regional adiposity and systemic insulin sensitivity.
The effect of insulin on regional cerebral blood flow was evaluated in 10 diabetic men utilizing quantitative dynamic positron emission tomography scanning of labeled water (H2O) [ 7].
