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37 Redistribution of blood flow away from metabolically active tissues, striated muscle in particular, caused by any mechanism leading to regional alterations in vascular resistance, would be expected to alter glucose metabolism.
In addition to the large regional alterations, the resolution of the BAC array allowed us to map smaller regions of gain or loss.
Luders, E. et al. Global and regional alterations of hippocampal anatomy in long-term meditation practitioners.
Medic, N. et al. Increased body mass index is associated with specific regional alterations in brain structure.
To identify regional alterations of white matter integrity associated with apathy in Alzheimer disease (AD).
The arterial wall material properties have been demonstrated to show regional alterations with atheroma development and growth.
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The approach we have used has previously been shown to reveal regional thalamic alterations that are consistent with focal alterations in thalamocortical connectivity [Hughes et al., 2012], and also corroborate the observation of thalamic changes using other morphometric approaches in patients with idiopathic generalized epilepsy [Kim et al., 2013; Saini et al., 2013].
However, there is increasing evidence demonstrating that, despite normalization of these global parameters, microcirculatory and regional perfusion alterations might occur, and persistence of these alterations has been associated with worse prognosis.
Evidence that different features of autism are caused by different genes associated with different brain regions [ 48] suggests a link between regional developmental alterations in the brain and different components of the autistic phenotype.
Correlating neural dysfunction and measures of atrophy between thalamus and temporal lobe has been suggestive of thalamotemporal network pathology, but there have been no attempts to identify regional thalamic alterations based on the determined cortical connectivity patterns of the thalamus, using multiple measures of tissue alteration.
The aim of this study was to investigate whether prelabour ruptured membranes at term display increased proteolytic activity and to determine whether regional structural alterations within membranes are reflective of regional variations in proteolytic activity.
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