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Furthermore, region-specific conditional Mecp2 knockout in neurons within either forebrain [13] or hypothalamus [19] caused an obese phenotype, which coincided with a significant reduction in Mecp2 expression in the hypothalamus [28] and is congruent with a possible role of Mecp2 as a transcriptional activator/repressor [42].
The metric is region specific.
Furthermore, adult cardiac specific conditional Snrk KO mice display severe cardiac functional deficits and lethality.
These changes were region specific.
The generation of rod-specific conditional IR knockout mice has been reported previously [ 26].
These adult and hepatocyte-specific conditional knockout mice also exhibited significantly enhanced regenerative capacity.
To this aim, we generated a satellite cell-specific conditional dio3 knockout mouse (see Experimental Procedures).
An epithelial cell-specific conditional mutant for Bmpr1a exhibited defective prostatic epithelial differentiation.
Mice with B lineage cell-specific conditional Myc inactivation were generated as described [ 15].
Here, we examine the effects of endothelium-specific conditional increase in ROS on coronary endothelial function.
Region-specific life tables were used to estimate life expectancy conditional on survival [44] with future life years discounted at 3%.
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