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We do not know whether the branch of the elliptic cone (25), mentioned in Proposition 6, coincides or not with the region of variation of the partial derivatives of quasiconformal mappings (f z)=u x,y)+iv y)).
In the case of P1, this region of variation has been mapped to a known surface-exposed domain [ 56].
Other variants found in these genes not in the large region of variation are listed in Additional file 3: Table S3 and Additional file 4: Table S4.
These SNPs are in near complete linkage disequilibrium (LD; D′=0.99; R=0.94) in the GWAS population and so were considered as a single region of variation, represented by rs4253238 for the remainder of this study.
The main region of variation between S. Derby D1 and D2 and S. Mbandaka M1 and M2 SPI-3 is at the start of the island where the complete S. Dublin SPI3 is present, this was shown previously for S. Derby 9813031, 0010160 and 0010158 [ 38, 39].
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Table 3 High and low frequency regions of variation distribution in 7302R genome Chr.
The large regions of variation in both the P1 and ORF6 genes are within RepMP sequences.
Most of these other variants, like the sequence of the large regions of variation, are subtype specific, rather than strain specific.
The ROI were selected specifically as the regions of variation in terms of X-ray attenuation which were located at the periphery/lateral side of the stem.
The sequences in regions of variation may influence interactions with the host and disease outcomes because they encode proteases, phospholipases and potential antifungal drug transporters.
Several regions of variation can be seen within Additional file 4: Figure S2 with the location of many phage genes, highly variable regions and antibiotic resistance genes denoted by colouring of the heat-map.
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