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The region (locus) of a chromosome that encodes an antibody is large and contains several distinct genes for each domain of the antibody the locus containing heavy chain genes (IGH@) is found on chromosome 14, and the loci containing lambda and kappa light chain genes (IGL@ and IGK@) are found on chromosomes 22 and 2 in humans.
Each genetic region (locus) was partitioned using BIC calculated in jMODELTEST v 3.06 (Table 2).
Furthermore, the LD blocks in the AIRE region locus are different in Caucasian and Asian populations.
Moreover, thymidine amplification was detected within exon IV, in an untranslated region (locus 7650).
A QTL is a DNA region (locus, pl. loci), harboring a gene or a regulatory element affecting a quantitative trait.
One SNP, located on the distal end of chromosome 12 near the γ3 heavy chain constant region locus, was typed as of donor origin in each mouse.
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Two binding sites were considered distinct if their seed region loci in the multiply aligned 3'UTR sequences were different.
In this genome-wide search, 44 loci were initially erroneously classified as coding region loci by UniGene, but ultimately reclassified correctly as 3'UTR loci after our own individual inspection.
The polymerase chain reaction primers and extension probes that were used to type met1 region loci are presented in supplementary table S1, Supplementary Material online.
Primer sequences, diagnostic polymorphisms, and polymorphism detection assays for met1 region loci are summarized in supplementary table S1, Supplementary Material online.
More dramatically, the BGLF3 gene overlaps four predicted structured regions (locus 163 to locus 166; Additional file 1), which span 84% of the coding region including part of the start codon.
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