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The Los Angeles region is problematic because storm water systems are separate from sewage systems.
But, he says, forming alliances in this region is problematic for the United States: "You can't work this out without some kind of relationship with Iran".
The latter region is problematic in both our map and the chicken sequence due to being the site of the protocadherin gene cluster.
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The assignment of disordered or unstructured regions is problematic, since by definition, these regions consist of an ensemble of rapidly inter-converting conformers that we cannot visualize.
Given that these regions are defined functionally, inferring an association between the structural results and one of these regions is problematic.
Reconstructing relationships among spidroins based on their repetitive regions is problematic because their extreme variability in length and sequence identity make them difficult to align [ 6, 7, 12].
In focally aberrant regions (<3 Mb) identification of driver genes is often straight forward, but it is our experience [ 38], acknowledged by others [ 39] that identification of candidate genes in larger chromosomal regions is problematic.
Current analytical methods mostly rely on sequence alignment against a unique reference genome, and unspecific mapping of short reads to repetitive regions is problematic with many events mediated by repetitive elements potentially being missed (Conrad et al., 2010a).
Repeat regions are problematic for alignment algorithms and users tend to mask sequences before performing the alignments.
While final calls were corrected manually, some regions were problematic.
We observed differences in the masking of repetitive sequences in Applied Biosystems vs. Illumina realignments, suggesting that repetitive regions are problematic for both platforms with short read sequencing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com