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The mountain club's High Peaks Region Guide describes the panorama from the summit as "one of the best views for the least effort in the Adirondacks".
Handsomely laid out and illustrated, the regional books devote a full page to each lodging so that the Mid-Atlantic and Chesapeake Region Guide, at 224 pages, contains only 104 choices.
In all cases, image guidance has become a necessary prerequisite to localise the target region, guide and document optimal deployment of the interventional device, and to evaluate success, failure or complications of the procedure.
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Base-pairing between the miRNAs and target mRNAs (usually in the 3′ untranslated region) guides RISC to complementary transcripts, leading to translation repression or the target mRNAs degradation [ 2].
This region guided the classification of Simonetta [ 13], who stated " [mallear] morphology pointed to three divergent evolutionary trends, so that the family could be... divided into three subfamilies" (p. 33 of ref. [ 13]).
Subsequently, the two proteins of interest are being chopped up to narrow down the interacting region, guided by the available knowledge of their modular domain architectures, including any solved structures of individual components.
It's also a stop on the Route des Sens Authentiques, a region-by-region guide to the island's artisanal producers, who've been making wine, charcuterie, cheese, honey, olive oil, chestnut flour and other items the same way for centuries.
But the core of the book is a region-by-region guide to notable cemeteries, from the enormous Native American burial mounds near Etowah, Georgia, to the recently disturbed cemeteries of New Orleans, where poignant handlettered signs ("So Sadly Misted") stand in for the sturdier monuments uprooted by Hurricane Katrina.
We rationally designed four variants of humanized scFvs V5B2 by resurfacing of variable regions guided by computer modelling.
In mouse, conversely, meiotic DSBs apparently target nucleosome bound regions guided by the methyltransferase PRMD9 (Smagulova et al., 2011).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com