Such computational tools would largely facilitate translational research by high-throughput identification and fast optimization of regimes of the network-based multi-target drugs with multiple '-omics' platforms.
While the sensitivity allows us to characterize the dynamical regime of the network, it does not directly inform on the information propagation capability of the network.
The mean sensitivity over all transfer functions in a network (S) has been used as an order parameter, that can be used to determine the dynamical regime of the network (order, critical or chaotic) [ 7], which affects the network's ability to propagate information [ 21].
As a result of this strategy, we obtain for each of the alternative networks a qualitative picture of the possible dynamic response regimes that the network may have.
With the first two parameters we controlled the regime of operation of the network (i.e., tristable or not), as well as the distance to the boundaries of the tristability range (S,C).
Hence, to a first approximation, self-interacting proteins can be simply ignored to establish the asymptotic conservation and topology regimes of PPI network evolution, as we have done in the main text and Fig. 3A.
In both cases, the flow regime in a given pipe of the network emerges as a result of pumping power minimization.
Comparison of these moduli for different chain architectures for each regime indicates that the stiffness of the network polymeric particle is consistently higher than that of the branched particle, which is consistently higher than that of the linear chain particle for all of the regimes.
Adding sites from parts of the river network with thermal regimes which differed from the rest of the network, and which were therefore highly influential, improved nearby predictions but reduced model-estimated precision of predictions in the rest of the network.
Since the organoclay cannot be interconnected in a high shear rate regime, the network structure of the clay is broken and a difference in the rheological properties among three fluids becomes negligible.
Mean decision times grow as the external input is reduced, regardless of the regime in which the network operates.
