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Because low regimen-switch rates may indicate delay in switching patients from failing first-line regimens, which could lead to poor long-term outcomes [20], [54] further research to better understand the reasons for low regimen-switch rates is planned.
This was obtained with fewer clinic visits compared with other regimens, which could ease the burden of nAMD treatment.
Alternatively, the cohorts differed in GVHD prophylaxis regimens, which could be responsible for the difference of acute GVHD incidence.
Another potential advantage of using only these 2 agents is that it spares nucleosides/tides in first-line regimens, which could possibly create more options for second- and third-line treatment.
Considering that the immune system plays a pivotal role in tumorigenesis, immunotherapy has been established as an important component of many cancer treatment regimens, which could destroy cancer cells both in situ and within the metastatic compartment [ 8– 10].
In the USA in particular, practitioners are being urged to await the results of RCTs prior to implementing CT screening regimens which could prove both ineffective and costly [ 7- 10].
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Surprisingly, AZT/d4T-associated mutations did not develop in patients 2 and 4 despite failing AZT/d4T containing regimen, which could indicate that the adherence to AZT/d4T treatment was too low to drive development of resistance [28].
With emergences of new paradigms in multi-target drug discovery for several complex diseases, multi-target virtual screening has been presented and executed to discover the regimen which could target many different proteins and could be of low cost, efficacy and better tolerance.
First of all, insulin-treated DM patients have worse clinical outcome regardless of the treatment regimen, which could either be due to more aggressive disease in these patients or an adverse effect of this insulin therapy [ 8].
The reason for this might be related to the small number of patients in each group, MEC regimen which could be related to fewer CINV events compared with an HEC regimen, and small number of female patients who are more prone to CINV, thus diluting the efficacy of the antiemetics.
Therefore, in our screening colonoscopy programs, it is advisable to involve the medical staff in patients' education prior to their procedures in order to increase the compliance with the bowl regimen, which could lead to an increase in the quality of our colonoscopies, and eventually the ADRs.
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