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For 34 7.2%) and 29 6.1%) patients, regimens were changed due to drug side effect and TB, respectively while the reasons for changing the initial regimen were not recorded for 99 (21.1%) patients.
Treatment regimens were changed in 71 (82%) patients due to severe adverse events or drug resistance.
Half of the HAART regimens were changed within the first year of follow up (Table 2).
In addition, some anti-hypertensive regimens were changed to ACEI therapy.
More than half (53%) of the regimens were changed within the first three months and nearly three quarters (71.2%) within six months of ART initiation.
63– 66 Other studies have reported a lowering of mitochondrial dysfunction when drug regimens were changed and nucleoside reverse transcriptase inhibitors were replaced with tenofovir.
Similar(52)
The risk that raltegravir is stopped prematurely or the salvage regimens are changed after initiation is low.
Within 14 days after changing the injection site, her insulin regimen was changed to 12 units of glargine at bedtime and premixed insulin (lispro 50/50; mid mixture) before meals: 16 units before breakfast, 4 units before lunch, and 10 units before dinner.
Those adverse effects may require that the drug dosage be reduced or the drug regimen be changed to make the drug tolerable to the patient.
On the advice of the on-call surgical team and the consultant microbiologist, the antibiotic regimen was changed to intravenous ceftazidine and metronidazole with oral cefalexin.
Owing to question about safety, the dosage regimen was changed, as follows: 5 mg (1 ml) of biperiden was diluted with 9 ml of saline resulting in a final dilution of 0.5 mg/ml.
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