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Genotypic susceptibility scores for the active regimens were calculated using scores defined by each interpretation system.
The ICERs of both boceprevir-based regimens were calculated in comparison with the PR48 treatment arm.
Direct medical costs of chemotherapy regimens were calculated from the hospital billing data of the patients.
Annual costs of individual HAART regimens were calculated using pharmacy data retrieved at each distribution site as of December 2012.
The Cmax/TRE, AUC0 48/TRE, and % T>TRE at different doses and dosing regimens were calculated using the Berkeley Madonna Software (version 8.0.1) (Berkeley Madonna, University of California, Berkeley, Berkeley, CA).
Disease stage costs per patient were collected; the expected disease progression in the absence of treatment and sustained virological response (SVR) success rate for SOF-based regimens were calculated based on the literature and expert opinion.
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Percentages for bisphosphonate treatment regimens are calculated with respect to the total number of patients taking a bisphosphonate.
Prices for a first line regimen were calculated presuming a six month regimen and dosing of 3.5 tablets (average of the two most common weight bands) of the WHO-recommended 4-drug FDC RHZE (for 2 months) and 2-drug FDC RH (for 4 months), or their single drug equivalents.
Probabilities of switching to the second-line regimen were calculated from primary data separately for months 6 12, 12 24, 24 36 and 36 48.
Relative dose intensities (RDI, the ratio between the actual dose delivered and the planned dose) for the different components of the treatment were regimen were calculated for both the phase I and phase II parts of the study.
Toxicity sum of a regimen was calculated as percent occurrences in the study cohort of severe adverse effects: diarrhea, mucositis, neurocutaneous conditions (excluding alopecia), vomiting, and febrile neutropenia.
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CEO of Professional Science Editing for Scientists @ prosciediting.com