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A statistically significant 4-year disease-free survival advantage was detected for the 2 dose-dense regimens compared with the regimens administered every 3 weeks.
The mean RFP domain scores were also significantly improved for both fremanezumab dose regimens compared with placebo (P≤0.001) as was the EF domain score for the fremanezumab monthly group (P<0.0001).
The degree of peak trough fluctuation (DFL, calculated as (Cmax − Cmin)/Cavg) in VPA concentration was less with both q12h (35.2% less) and once-daily (16.9% less) divalproex-ER regimens compared with q6h divalproex (P ⩽ 0.024).
The relatively poor outcome in adult ALL has been explained by an increased frequency of high-risk molecular subtypes with more aggressive clinical behavior and greater drug resistance, poorer tolerance and compliance with treatment, and less effective treatment regimens compared with childhood ALL [6], [8], [9].
In addition, multiple insulin analogs are now available (34) with improved kinetics and safer dosing profiles permitting more individualized and safer regimens compared with prior preparations.
Other retrospective and prospective reports have not demonstrated increased weight gain with anthracycline-containing regimens compared with other regimens [ 10, 11].
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Still, it is unclear exactly how much better people with H.I.V. will stick to a once-daily regimen compared with one requiring two pills a day.
We designed a prospective, multicenter, randomized, controlled study to assess a 5-month regimen compared with the standard regimen on previously treated patients with pulmonary tuberculosis (TB).
We examined the effect of a tailored pill regimen, compared with the standard regimen, on continuation and satisfaction rates at 1 year and associated bleeding patterns.
This study was conducted to compare ovarian activity of an oral contraceptive containing drospirenone (drsp) 3 mg plus ethinylestradiol (EE) 20 mcg administered in 24/4 regimen compared with the conventional 21/7 regimen, during intended use and following predefined dosing errors.
The response data are too preliminary for speculation about the relative benefits of this 3-drug regimen compared with the combination of only docetaxel and estramustine in this clinical setting.
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