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The bleeding risk associated with concurrent PPI and NSAID treatment was similar for each antithrombotic regimen (supplementary table 3).
Similarly, BMI was not different by insulin regimen and did not increase over time more dramatically on any particular regimen (Supplementary Table 3).
Their average body mass was 72 ± 10 kg (54 85 kg); they had a BMI of 25 ± 3 kg/m (22 30 kg/m) and a total daily dose (TDD) of insulin of 0.45 ± 0.09 units/kg (0.31 0.56 units/kg) with their usual insulin regimen (Supplementary Table 1).
Patients who opted for chemotherapy received pemetrexed and cisplatin or carboplatin, up to a maximum of six cycles at 21-day intervals according to a standardised regimen (Supplementary Information 2 online).
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In detailed comparison for nausea or vomiting, there were no significant differences observed amongst all the regimens (Supplementary Figure S1).
Patients' characteristics were similar in the internal and external validation cohorts, with the exceptions of PS and regimens (Supplementary Table S3).
Furthermore, we found no significant difference in plaque growth between these two dosing regimens (Supplementary Fig. S1a), therefore we pooled the data for all further analyses.
Specifically, BRAF mutation predicted more rapid disease progression in patients treated with first-line oxaliplatin- (HR 6.4, 95% CI 2.6 15.6), irinotecan- (HR 4.1, 95% CI 1.5 11.3), or oxaliplatin and irinotecan (HR 7.9, 95% CI 1.3 48.2), as well as bevacizumab-containing (HR 5.1, 95% CI 2.4 11.1) regimens (Supplementary Table 3).
As for initial therapy, novel agents were not administered in the 1990 2000 cohort, and most of the patients (90.8%) were treated with conventional chemotherapy alone such as melphalan+prednisolone, and the remaining 9.2% patients were treated with ASCT after the induction therapy with vincristine, adriamycin and dexamethasone or other conventional regimens (Supplementary Table 1).
Treatment groups were also balanced regarding the types of chemotherapy regimens used, with most subjects receiving single-day regimens (71.3% and 69.9% for fosaprepitant and control regimens, respectively; supplementary Table S2, available at Annals of Oncology online).
No heterogeneity or publication bias was identified among those pairwise comparisons of different treatment regimens (see supplementary table A).
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