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All monthly regimens were proven non-inferior, and the 150 mg regimen superior, to the daily regimen.
Indeed, according to the Norton Simon model and based on the apparently excellent DFS in the Bonadonna trial, many oncologists have deemed the sequential regimen superior to those regimen in which the anthracycline was replacing a CMF drug (i.e. FAC/CAF (cyclophosphamide, doxorubicin, 5-fluorouracil) regimens).
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This may reflect the fact that the changes patients make in their treatment regimens are made in response to the belief that a new regimen is superior to a previous one (and, if it is not superior, they may discontinue or make another change).
Analyses using different landmark time points gave conflicting results: the 4D regimen was superior at 1 month and at 3 months, whereas at 2 months the 2D regimen appeared superior.
While both groups improved, neither regimen is superior to the other in patients with trapeziometacarpal osteoarthritis.
However, there is no consensus as to which oxaliplatin/5-FU containing regimen is superioxaliplatin/5-FU containingg.
There's a lot of advice out there about how to win a race: "Be fast out of the gate," "slow and steady," and, most importantly, "make sure your doping regimen is superior to the competition's".
The recently reported COMET trial found that the β1/β2/α1 receptor blocking agent carvedilol given in a relatively high β1-receptor blocking dose regimen was superior in mortality reduction to immediate release metoprolol given in a relatively low β1-receptor blocking dose schedule.
Restricted analysis allowing for a post-treatment prophylactic effect confirmed that the 8-week regimen was superior to current treatment.
Fosaprepitant regimen was superior to the control regimen for no vomiting in the overall phase (treatment difference 9.8%; P < 0.001).
The twice-daily Mix 25 regimen provided superior overnight glycemic control compared to the Mix 50 regimen in Japanese patients with type 2 diabetes.
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