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Data include patient characteristics such as age and gender, and the quantity and regimen information of all dispensed medication.
Given the lack of available pre-ASCT induction regimen information in our database, we could not extract the data for patients with MM who actually received novel agents during the novel agent era for our analysis.
Drug regimen information was cross checked against pharmacy data for accuracy.
An additional 64 patients who did not receive the PF regimen as NACT or whose chemotherapy regimen information was incomplete were excluded.
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Depending on the step of the algorithm further subroutines of the CDSS provide additional data to be displayed (e.g. newly adjusted dosage regimens, information about tablet splitting, or hints and warnings related to the suggested substitution).
Lipid levels, body and spleen weight were not influenced by this regimen (Supporting Information Table 2 and 3).
In many cases, particularly those in which the patient has no additional risk factors and is adherent to the recommended screening regimen, this information is sufficient.
Patients who opted for chemotherapy received pemetrexed and cisplatin or carboplatin, up to a maximum of six cycles at 21-day intervals according to a standardised regimen (Supplementary Information 2 online).
Even if prognostic signatures supplement traditional clinicopathological parameters in the stratification of risk in primary breast cancer, existing datasets provide little information guiding treatment regimen choice for individual patients.
Neoadjuvant chemotherapy comprised treatment with three cycles of epirubicin, cisplatin and capecitabine, and palliative treatment comprised up to eight cycles of epirubicin, oxaliplatin and capecitabine (regimen details provided in Supplementary Information 1).
Information about drug regimen changes is a vital part of the patient transfer process from hospital into primary care, because many drug changes must be followed up and evaluated in the postdischarge period.
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CEO of Professional Science Editing for Scientists @ prosciediting.com