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Patients obtaining a suboptimal response or progressing on first-line treatment were switched to the opposite regimen in case they were determined to be in need of additional chemotherapy by the treating physician.
The most common empiric antibiotic regimen in case of clinical suspicion of severe nosocomial sepsis was imipenem for the coverage of A. baumannii and P. aeruginosa.
One-fifth of the neonates received ceftriaxone, in most cases as a second-line regimen in case of unsatisfactory response to the first regimen.
Our data suggest that in patients with advanced colorectal cancer an interrupted treatment strategy, i.e. retreatment with the same regimen in case of relapse > or = 3 months after discontinuation of 6 months of successful treatment with 5-FU/LV or 5-FU/LLV is an acceptable therapeutic concept.
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Individual institutional utilization of modern information technology, e.g. electronic medical record system, is also certainly important in promotion of new treatment guidelines and will aid in minimizing inappropriate use of treatment regimen in the case that guidelines are modified [19], [20].
There are no individual selection criteria for the use of any tuberculosis treatment regimen in new cases in Brazil.
A total of 940 tumors were examined, derived from an equal number of patients who had participated in two randomized clinical trials (paclitaxel-containing regimen in 793 cases).
Although our series was relatively small and some differences existed among other factors, the effectiveness of our treatment regimen in severe cases was comparable with that of earlier report.
In conclusion, the combination of irinotecan and carboplatin is an active and well-tolerated regimen in cases of SCLC.
In the first line drug regimen, side effects were more frequently responsible of the change of the drug regimen in cases compared with controls, although not reaching a statistically significant level (p = 0.1).
The high efficacy of MACOP-B may also suggest a role for antracyclines and cyclophosphamide in adult LCH, in line with previous reports investigating dose dense regimens [ 12, 13], and with anecdotal case reports suggesting efficacy of antracycline based regimens in case of lymphomas or leukemias coexisting with LCH [ 14, 15].
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