These parameters include the appropriateness of indication, dosing regimen, duration of therapy and monitoring for toxicity.
We conducted a similar process of modeling, in which, for certain factors with multiple levels – race, age, risk for HIV acquisition, ARVT regimen type, regimen duration, and number of drugs in regimen – if any level of the factor was significant, all levels of the factor would be retained in the model, regardless of significance.
The total intended drug dose and regimen duration in both groups were comparable.
Patients receiving an STR had a mean regimen duration of 348 days; this was approximately 2.8 months shorter than the mean regimen duration of 433 days observed for patients receiving 2+PPD.
Even with the combined regimen, duration of therapy with regular SAG injections did not significantly alter and hence there was no noticeable decrease in the overall dropout rate.
Furthermore, with current treatments, regimen duration and rates of treatment success are highly dependent on the infecting genotype, which varies significantly in its relative prevalence worldwide.
Putative risk factors for dyslipidaemia included: age, sex, CD4 count, ART regimen, duration of and adherence to ART, smoking, alcohol use, presence of metabolic and/or cardiovascular disease.
Univariable analysis was performed for the following variables: Sex, age, WHO stage, initial ART regimen, duration of ART, body mass index, hemoglobin level and total lymphocyte count.
Some additional patient information was not available for analysis, including duration of hypertension or diabetes, patient compliance with prescribed antihypertensive and antidiabetic medication regimen, duration of medication use, and patient insurance status.
The reasons for heterogeneity in treatment effects include dosage regimen, duration of therapy, trial quality, publication date and whether patients had septic shock or other forms of severe sepsis [ 153].
This work was a retrospective study and we had no access to patient clinical data (antiretroviral treatment regimen, duration of HAART, CD4+ count, HIV viral load, CDC stage) that might have affected our results.
