Exact(7)
While we were unable to include the carrageenan vehicle controls for this every other day regimen, comparison to the daily-applied carrageenan control group, in which a greater non-specific barrier effect would be expected than for an every other day dosing regimen, revealed marked protection (67%, 11 of 14 protected; zinc acetate and MIV-150/zinc acetate data combined, p<0.06).
By applying similar analysis approach to other drugs, dedicated clinical trials for regimen comparison may be reduced.
Sensitivity analyses for the extended versus 12 month regimen comparison after inclusion of the PRODIGY landmark analysis are in web figures 12-18.
In Figure 1 and Additional file 1: Figures S2-S12, plates D present regimen comparison between patient purchase and nurse reporting.
These analyses showed highly consistent findings with the main results, except for all cause mortality, which became of borderline significance (P=0.05) in the extended versus 12 month regimen comparison.
Bibliographic details, study research question(s)/objective(s), study design, number of participants, study duration, intervention(s) (insulin type, dose and regimen), comparison(s) (insulin type, dose and regimen) and relevant quantitative results for the primary and secondary outcomes of interest were extracted.
Similar(53)
Thus meta-analyses are reported separately for different regimen comparisons, which we label A-E.
As evident in our analysis, regimen comparisons will depend on the outcome metrics used.
MACE outcomes were reported by one cohort study 17 that included adjusted point estimates for four different insulin regimen comparisons.
The use of combined magnesium- and calcium-based phosphate binder regimens allows a reduction in the calcium load, and magnesium and calcium regimen comparisons show that magnesium may be as effective a phosphate binder as calcium.
In addition to standard meta-analysis, mixed treatment comparisons were also performed to allow the inference of indirect evidence (regimen comparisons without randomised controlled trials) and thus a network of evidence [ 24].
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