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Firstly, unmeasured confounders relating to regimen choice could have distorted findings.
Distinguishing between contamination and true positives can be difficult [ 8], and clinicians may benefit from ASP assistance with regimen choice and education surrounding contamination potential.
Regimen choice was subject to availability, with use of a generic fixed-dose combination of d4T, 3TC and NVP whenever possible.
In any case, further research is warranted into the patient and healthcare factors influencing regimen choice, such as the acceptability and potential impact of a preferred medicine scheme.
The challenge is how to reliably identify and validate biomarkers of drug sensitivity and resistance and how to integrate these into future clinical strategies combined with optimal prognostic methods in order to stratify risk and guide regimen choice.
Although substantiated by little evidence, concerns about zidovudine-related anaemia in pregnancy have influenced antiretroviral (ARV) regimen choice for preventing mother-to-child transmission of HIV-1, especially in settings where anaemia is common.
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As the new WHO guidelines recommend phasing out the use of d4T (WHO, 2009a), awareness of this potential risk should be raised and strategies for more appropriate regimen choices should be discussed.
Radio buttons take similar arguments to selection boxes by commonly sharing choices and selected: radioButtons ("SELECT", "Dosing Regimen:", choices = list("Loading-Bolus-Bolus" = 1, "Loading-Continuous Infusion" = 2), selected = 1), As there are only two options, the radio buttons display all possible options to the user without adding considerable length to the sidebar.
The advent of rapid molecular assays, such as the Xpert MTB/RIF assay, that are able to detect key drug resistance mutations in the initial diagnostic sample now permit appropriate regimen choices to be made at the start of treatment [ 21].
Objectives: analyzing ART regimens prescribed in newly HIV-infected patients, identifying the factors that influenced regimens choice and analyzing viro-immunological evolution under therapy.
Women were randomised to receive fluorouracil600/epirubicin60/cyclophosphamide600 for four cycles followed by docetaxel100 for four cycles (FEC-D) or one of two standard regimens (choice declared by each centre at trial outset): F600E60C600 for eight cycles (FEC) or epirubicin100 for four cycles followed by cyclophosphamide600x2/methotrexate40x2/fluorouracil600x2 for four cycles (E-CMF) [19].
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