Sentence examples for regenerative pathway from inspiring English sources

Our in vitro data suggested that Ndel1 works upstream of or at least serially with neuronal Vimentin in the regenerative pathway as co-silencing of Ndel1 and Vimentin does not further impede outgrowth of lesion-conditioned DRG neurons when compared to neurons treated with Ndel1 siRNA (Fig. 5).

Thus, maintenance of the regenerative pathway by PFD may influence cancer cell adherence in the ex vivo system.

In addition to trophic support (Soares et al., 2014), Schwann cells might control the mechanical forces acting on axons, which could bias the frequency of either regenerative pathway.

Finally, they showed that this regenerative pathway involves Ca2+ signalling (known to be important in neuronal responses to injury) and specifically the conserved Ca2+-binding protein calreticulin.

The authors propose a model whereby injury-induced Ca2+ signalling amplified by calreticulin promotes CED-4-mediated activation of CED-3, which then acts upstream of a DLK-1-mediated regenerative pathway.

Following severe or chronic injury, hepatocyte regeneration is impaired and an alternative regenerative pathway involving hepatic progenitor cells (HPCs) can be activated, which is associated with the development of ductular reactions (DRs) and progressive fibrosis, both in humans and mouse models of CLD [ 2– 4].

We posit that these regenerative pathways are critical in mammals.

These intrinsic regenerative pathways are integrated across different skin compartments and are being elucidated on the cellular and molecular levels.

Because essential components of a process tend to be conserved over the course of evolution, identifying regenerative pathways shared by many species would be a powerful method to uncover as yet unknown regulators of regeneration.

In this regard, substantial efforts to enhance the efficacy and safety of cell therapy are continuously growing along several fronts, including modifications to improve the reprogramming efficiency of inducible pluripotent stem cells (iPS), genetic engineering of adult stem cells, and administration of growth factors or small molecules to activate regenerative pathways in the injured heart.

However, technical difficulty to isolate and characterize these progenitor types due to the complex lung structure continues to hinder the understanding of the role of endogenous regenerative pathways in lung tissue maintenance and repair in response to injuries.