The explanatory concept of 'speculative states' is developed to understand India's intervention in the regenerative medicine knowledge production process [ 87, 88].
Even though MSCs and EPCs constitute a powerful candidate cell type for regenerative medicine, more knowledge in terms of their biological properties is required before using these cells as a routinely applied therapy in the clinical setting.
Tissue engineering and regenerative medicine incorporate knowledge from the areas of biology, materials science, and engineering to repair, restore, and regenerate living tissues that may have been compromised by disease, injury, or other means [ 3, 4].
For example, in the field of regenerative medicine, the knowledge about bone homing has been utilized to develop drugs directly able to arrive on their targets in the bone.
Modern techniques and advanced knowledge of regenerative medicine have led to a deeper understanding of the microstructure, microphysiology, and micropathophysiology of vocal fold tissues.
The combined use of nanoparticles and human mesenchymal stem cells (hMSCs) in tissue engineering and regenerative medicine requires more knowledge of the influence of nanoparticles on cell viability and differentiation potential of hMSCs.
An important aspect in understanding regenerative processes is the knowledge about the cellular origin of the regenerated tissue.
No formal representation or computational tools exist to efficiently store, search, or mine the available knowledge from regenerative experiments, inhibiting fundamental insights from this huge dataset.
- There is potential to harness this knowledge for regenerative therapies, recreating the required mechanical and signalling environment to guide the formation of robust cartilage and bone tissues from stem cells in culture.
Finally, the future of these technologies in sports medicine requires an understanding of these complex materials, the engineering of the adequate regenerative material on demand, and knowledge of how to use them in the clinical situation.
Nobody had put together the architecture for a regenerative design approach that drew on knowledge of traditional cultures while adapting to the opportunities of new technologies and systems thinking.
