However, in cats, both in vitro and ex vivo studies have shown a ratio of only 2.7 in regards to selectivity of COX-2 inhibition over COX-1 [ 43].
Emerging evidence has reported that nucleic acid-sensing TLRs seem to play a critical role in recognition of viral nucleic acids, both with regards to selectivity of their ligands, pathogens and differential recognition of foreign versus self nucleic acids [ 6, 7].
With regard to selectivity (Supporting Information Figure 2), (2) DEVD- RGSN was 49-fold selective for caspase-3 compared to only a 9-fold increase in selectivity when P1′ Gly is retained.
Further discussions with regard to selectivity among different divalent cations are also incorporated (see below).
The autothermal reforming performance of the reformer for different fuels was evaluated with regard to hydrogen selectivity, COx selectivity, and energy conversion efficiency.
Furthermore, the functional nature of these C-terminal targeting signals with regards to their membrane selectivity have been shown to be conveyed, not by primary sequence motifs, but, rather, by distinct physico-chemical properties, such as their net charge and/or the overall hydrophobicity of the TMD.
These classes of compounds differ with regards to their substrate selectivity and specificity, which in turn impacts their anti-tumour activity and mechanism of action.
Both modes of readout, however, differ considerably with regard to gas selectivity: whereas in the vertical readout mode a relatively high level of amine selectivity is observed, only a broad-range selectivity is observed in the planar mode.
With regard to reactant selectivity, the dendrimer can, in some cases, provide a means for controlling product selectivity via the sterically confined environment within the dendrimer nanoreactor.
Since the hydrophobicity of the solvent may also play an important role with regard to enzyme selectivity and activity, 51, 52 three different solvents were selected: methyl tert-butyl ether (MTBE, log P=0.94), toluene (log P=2.73), and octane (log P=5.15).
The results are discussed with regard to female selectivity for call parameters that are likely to mediate sexual selection and homospecific pairing.
