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Participants in the REGARDS cohort could be significantly different from prior studied populations.
The REGARDS cohort does not include Hispanics, where stroke mortality disparities are small to nonexistent.
The REGARDS cohort was recruited between January 2003 and October 2007.
The REGARDS cohort encompasses healthy community-dwelling adults not just individuals with a history of stroke.
The national distribution of the REGARDS cohort is shown in Figure 1.
Baseline data were analyzed from the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.
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Additional file 1: Detailed information regarding cohort follow-up and censoring, maltreatment classification, and data linkage methods.
For our comparison, we select three generalizations suggested by Renshaw and Haberman (2003; 2006) who add terms regarding cohort and extra-period effects.
We performed sensitivity analyses of key assumptions regarding cohort selection.
For our analyses, we reviewed all cohort studies published since 1995, which provided basic descriptive information (regarding cohort assembly, demographics, person-time of observation, etc)., and cancer outcomes.
In terms of applicability, there was high concern regarding cohort selection, technique, interpretation of results, and threshold decision in all the included studies as summarized in Table 5.
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